Factor IX levels and oestrogens.

Functions of the Heterologous Intron-Derived Fragments Intra and Extra Factor IX-cDNA Coding Region on the Human Factor IX Expression in HepG2 and Hek-293T Cells

Background: Human FIX (hFIX) gene transfer into hepatocytes has provided a novel approach for treatment of hemophilia B. To obtain an improved expression of hFIX, the functional hFIX-expressing plasmids with appropriate intron-derived fragments which facilitate transcription and promote an efficient 3′-end formation of mRNAs are required.Objectives: We ai...

The effect of oestrogens and progestogens on serum protein levels.

contraceptives. Significant increases in macroglobulin, transferrin, and IgG were found but albumin was unchanged. The purpose of the present experiment was to determine whether the oestrogen or progestogen component was responsible for these changes. Two groups of 14 healthy females were given either 50 mg oestrogen (mestranol) or 1 mg progestogen (ethynodiol diacetate) daily for three weeks. ...

FIRST SURVEY OF FACTOR IX INHIBITOR IN NORTHEASTERN IRAN

Expression and characterization of human factor IX and factor IX-factor X chimeras in mouse C127 cells.

Human blood clotting factor IX, and two chimeric molecules of factor IX, in which the first epidermal growth factor-like domain or both epidermal growth factor-like domains have been replaced by that of human factor X, have been expressed in mouse C127 cells. The recombinants have been purified using a metal ion-dependent monoclonal antibody specific for residues 1-42 of human factor IX. All re...

Haemophilia B (Factor IX Deficiency)

If a woman is a carrier there is a 1 in 2 chance that any son will be affected and a 1 in 2 chance that any daughter will be a carrier. If a man with the disease fathers a child, any daughter will be a carrier and any son will be unaffected and will not carry the gene. There is a report of a daughter of a man with the disease who had a factor IX level of 5% and haemarthroses and this was though...